How GLP-1 Impacts Fat Loss & Hunger in Women I Sarah Kennedy

Speaker A: 00:00:00

What most people don't realize is hunger is an evolutionary trait which was an asset to us during evolution. And it's controlled by our hind brain. If you reduce your calories by 25%, your hunger will double over four months.

And that's stimulated by ghrelin, which is the hunger hormone. Now, the reason for this is your body thinks it's going into a famine. And this is what forced us out of our caves and said, hey, go out and hunt.

So it was an asset to us. Now, in the developed world, we're surrounded by food, so it's not so much of an asset. And this is why 99% of diets fail. And women. And men.

But let's talk about women. Get into this, this love, hate relationship with food because it's all said, it's about willpower. It is not about willpower. You know it is.

That's your forebrain, and your forebrain sits over your hind brain and your forebrain saying, you don't need to eat this. You put stress hormones, lack of sleep or alcohol, and that forebrain falls off. And that hindbrain goes, whoa, we're off.

So I always say to people, how many times have you had hot chips late at night after you've had something to drink? There's a lot of stigma around. You don't have willpower. You can't do that. It is biological.

It is your body saying your body fights you the whole time. So we are just a tool to help you with that.

Speaker B: 00:01:47

Welcome to the Optimized Woman, the podcast for high performing women ready to take back their health. I'm Orshi Vangotten, a board certified holistic health practitioner and functional nutritionist.

If you're tired of feeling stuck, you can't lose the weight. No matter what you do, your energy's in the toilet and you lost the spark you once had. Then you are in the right place.

We are here to unleash the unstoppable force you're meant to be and give you the tools to fix what's holding you back. So if you're ready to own it, start thriving again, and live the life you deserve, then let's get to it.

What if a plant compound you probably never heard of could naturally help control hunger, reduce cravings, and support real weight loss without medications or stimulants? Today, I'm joined by Sarah Kennedy from New Zealand to explore a breakthrough backed by more than $20 million in government funded research.

It's one of the only natural compounds to ever go through the same rigorous scientific process used in pharmaceutical development, including double blind placebo controlled human trials. I rarely feature supplements on this show, but this is different. It's not hype, it's not marketing.

This is real science that's uncovering how specific plant compounds can tap into your body's natural hunger signals and possibly offer a powerful tool for women who want safer, more sustainable options for metabolic health.

So if you've ever wondered why hunger can feel impossible to manage, or how science is uncovering new, safer ways to change that, you want to hear the full story? So let's get into it.

Speaker A: 00:03:23

In: 2010

ow remember, this was back in: 2010

Kalahari tribesmen going out on a hunt would chew very, very bitter cactus to suppress their appetite. In fact, that was the origin of an older herb called, or an older ingredient called hoodia.

And then some more recent work had been done in animal studies with bitter substances. So they applied for a grant and the grant was called Foods for Appetite Control.

And they got back a $20 million grant from the New Zealand government, which was about 15 million US in those days. They did some extraordinary work, but the basis of it was that bitter suppresses appetite. Now why would bitter suppress appetite?

It's actually an evolutionary adaptation because bitter was obviously, it was often associated with toxic. So when we put something bitter on our tongue, we spit it out.

If it goes into our stomach, we'll feel nauseous or we will release an appetite stimulating hormone to make us eat more to try and dissipate anything that was toxic.

If it goes into our upper intestinal tract, it will stimulate the release of, of appetite suppressing hormones because you can't vomit it out, you can't spit it out. So your body's saying, hey, stop eating. This could be toxic. So that's sort of the genesis or the basis for bitter tasting.

So what they actually did in this and with the grant, they actually took biopsies from 300, 300 biopsies from humans right down through the gastrointestinal tract, the stomach and right the way down to the colon. They looked at those and they then mapped all of our bitter taste receptors.

So that's the first Time in the world that that's been done and that paper's just been published. But they mapped them all down and now they had these bitter taste receptors which are in our L cells.

They then showed that these bitter taste receptors in the upper intestine released appetite suppressing hormones. Then they built a high throughput enteroendothelial model. And this is the key part.

They tested over 1,000 different extracts on this model to see what would produce the most amount of these appetite suppressing hormones. And out of a thousand extracts there was really only one and it came from a variety of hops.

Now this is not hops, which is what you use to flavor beer. Now this is actually not surprising because if you think about it, if we reacted to all bitter things, we'd have a cup of coffee and stop eating.

So it really has to be potent. So they found this one plant extract that did it.

And because they're plant breeding experts in New Zealand, they went through 50 other varieties of hops to get what they called the Eureka, this extract. And that's what they called amerisate. Scientists always pick weird names but amera means bitter and sait means satiation. So they picked that.

They knew they could get this release in the laboratory. They then went and formulated it into a supplement so it would disperse properly and, and all of these things they tried it on themselves.

They then took it into their first human clinical. So we knew it, they knew it worked in the laboratory, but would it work in humans?

And it was, it was a big trial, when I say a big trial, quite an expensive trial because it was 20 men, but you cannulate them so you can take bloods the whole time.

And so they had 20 men cannulated and they gave the capsule containing Amarisate an hour before an eat til you full lunch and an eat til you full snack.

And they measured the blood all the way through for the next four hours and they could show this peak in CCK which is an appetite suppressing hormone, GLP1, which we all know and PYY. So it stimulated it at 600% above baseline, so twice what you would have when you eat.

And this gave an 18, an average of an 18% reduction in calorie intake. So we then knew that we could super stimulate these L cells and spike these three appetite suppressing hormones with reduction in calories.

ars and then was presented in: 2006

That's when I was approached to say, hey, and this is what happens. They will get to and they go, we think this can be commercialized. How should we commercialize it? And they approached me and said, what should we do?

And I from all my years in nutraceuticals and supplements, I had never seen this amount of science on, you know, in a category there's only three things. There's fillers, there's stimulators, and there's laxative.

was approved in: 2021

Speaker B: 00:10:15

Yes. And since then, GLP1s have become a buzzword in the weight loss world with the, you know, rise of the injectable peptides.

First, can you explain the role of GLP1s? How does that play a role in appetite and weight regulation?

And then also help us understand the lesser known but equally important hormones like the PYY and CCK that you mentioned. How do these three peptides interact and what's like the significance of triggering them together?

Especially when we are looking at natural approaches like amerisate and kurb that stimul this cascade through the gut brain axis.

Speaker A: 00:10:58

Yeah, look, it's a great question and I'm not sure many people understand, but we all are hormonally driven and biologically driven. This is our gut brain axis.

So when you eat, it goes into your stomach and you digest it down and then it goes into your upper intestine and this is when it stimulates you stimulate your own GLP1 CCK, GLP1 GIP and PY and this is our feedback mechanism to tell you to stop eating because otherwise we would pop. But as you know, this happens 45 minutes after you've eaten.

And often if you think about it, you'll get, you know, 45 minutes after a large meal you go, oh, I wish I hadn't eaten that much. And that's your brain signaling you to stop eating. You know, remember your mother used to say chew your to your mouth for 40 times.

And that was just slowing down. You know, you're eating, so probably you're signaling earlier. But you know, we're all in a rush and we all eat things on the run.

So usually this comes afterwards. So it is a natural hormone produced in your body. And as a feedback loop, what we do or what color curve does is we super stimulate these L cells.

So we double the amount of GLP1, CCK and PYY that you produce.

So we're going to decrease hunger but if you take it an hour or an hour and a half before a meal of course we're going to tell your brain that you're full partway through your eating which is why you eat less. So we're just, we're a hack for our hunger I suppose.

And so that's how it works when we talk about 3 GLP1 is probably the best known because that was the first injectable on the market either. Well as wegovy but there are other appetite suppressing hormones and they're all important.

So CCK is in the very top of your, just after your stomach and it's very potent but very short lived. And then as you go down the intestinal tract you'll stimulate GLP1 and lastly at the bottom pyy so they're all important and they all interlink.

And by having three, you know it's thought you get a lot less side effects because it's a lot more natural because you're stimulating the three hormones versus just one. The other one that I like with CCK and why gastrointestinal doctors are very excited is it actually squeezes the gallbladder.

It stimulates the gallbladder to squeeze. Now that is quite important because one of the side effects of an injectable GLP1 is gallstones because you're not squeezing that gallbladder.

So we do cck. So when gastroenterologists came up to us they're like wow, you know, you know you squeeze the gallbladder.

Well I didn't know that because I only knew a balm. It's telling your brain you're full and it's slowing down your gastric motility. So that's really what these natural hormones do.

They also increase the amount of insulin produced and so they help the uptake of glucose from the blood. But a big thing, what they do in weight management is suppress that appetite.

And because Kellokkurp is only focused on the gut, like only focus, less than 1% is in the bloodstream. We travel all the way down and we're firing these L cells as we go down, which is why we last for four to six hours.

The difference with an injectable is you are injecting in a synthetic hormone and that synthetic hormone, it's GLP1 has had one molecule altered in it. So it lasts for seven days, not the two to three minutes that your body has naturally.

So you inject it at a high level and then it decreases over seven days, which is fine. But just understand your body doesn't need high TLP1 when you're asleep. You really want high GLP1 before you eat or to stop you being hungry.

So GLP1 CCK PYY are natural in your body.

Speaker B: 00:15:37

So compared to the injectable ones, just to try to summarize it, the injectable is sort of an artificial hormone replacement in many ways.

We are giving you a really large amount of GLP1s and it stays in your body for about a, about a week and slowly declines versus this is a more natural synergistic interaction with your gut, your entire GI tract and the way your stomach's supposed to function and secrete all the gastric juices and the whole process is more natural. So you take it about an hour, an hour and a half before you eat.

Then by the time you eat, you're not hungry and you eat about half, half the food that you ignore or.

Speaker A: 00:16:24

Maybe 30%, there's about 18% less calories and you know, you just feel full faster. And the other thing is it lasts for longer.

So for people at after dinner snack, you know, you finished your dinner and you're sitting in front of television, it's like, oh, I'll have something sweet. That really helps for that after dinner because it lasts for four to six hours and you're full, your brain's telling you you're full.

And I always say I take mine, I intermittent fast, so I take mine about 8 o' clock in the morning. So morning tea, all of those things, I can just walk past. I don't need that muffin. It's just a wonderful tool to help manage your hunger.

So we have done two more human clinical trials and in them we looked at hunger and craving. We did this both in men and women.

And I'm the most proudest of the woman because you know, you would know that women, you normally don't do clinical trials on women or you don't ever start off with women because women have hormones and this is really annoying in a clinical trial. So we did this and we did three doses, so placebo, low dose, high dose, on 30 women, which means we have to repeat the trials three times.

So it's in fact 90 women, but it's on 30 women three times. But with women you have to line them up in the exact stage of their menstrual cycle. So you can't do it.

You've Got to line them up on that exact time and on the exact same day of the week. So because if you did on a Sunday, people's eating habits are different on a Wednesday.

So you imagine the calculations, the chief scientist nearly went nuts. And it was during COVID So it took around 18 months and quarter of a million dollars. But I'm so proud of it.

The results were just stunning and really showed that women are more sensitive to GLP1 stimulation. So what it was, it was a 24 hour water only fast. And Calicob was given at 16 hours and at 20 hours. Now why was that?

The last eight hours of a 24 hour fast is when you're gonna be the hungriest. We reduced hunger by 100%. So, so they were no more hungry at 24 hours than they were at 16 hours. Now remember, that's comparing to the placebo.

And then we measured craving and it was 120% decrease in craving. So they were craving less at 24 hours than they had been at 16 hours.

We then gave a calorie counted meal and at 24 hours and they ate 14 and a half percent less than placebo. So that's why we say on average a 30% reduction in hunger, a 40% reduction in craving and an average of an 18%.

But if you think about it like that, it can really help women during their menstrual cycle in the luteal phase, or what we call pms, right? Women will eat up to will on average eat 250 calories more a day and up to 600 calories more a day.

Now if you think about that, that is your body telling you you might fertilize this egg and I want you to have the best environment possible for that, which is why you eat more. So it's a natural biological, it's an evolutionary trait.

But of course you, you know, we don't want to implant an egg every month, but this happens every month.

So I think Calicob, you know, can be incredible during, you know what, that week of what we would typically call pm where you're hungry and you can control that craving, but you know, all the time is fine too. But just think of that week when it's probably double the amount.

Speaker B: 00:21:22

I love that there was special research done on female participants because that's so rarely done.

And I'm so glad that companies are actually investing into that because even with the injectable ones, I think even the injectable peptides, women respond at higher rates than men. But, but you probably knew this before the injectables came out because you guys are already done your trials. One question I have about the trial.

You mentioned that there was a placebo and a low dose and a high dose. What how many capsules were taken? Can you tell me like what the low and the high dose is and what the difference was in the trial?

Speaker A: 00:21:59

The high dose is what we recommend on the bottle, which is two, the tiny capsules, two small capsules, an hour to an hour and a half before a main meal. So that's 250 milligrams. The low dose was 125 milligrams. The low dose still works. Just it wasn't as high.

And we always get patients, people to what we call onboard with these capsules. So take one a day for two days, take two a day for two days, and then you get up to two before each main meal.

The point is that each person is different or physiologically different. And we think it's because some people have more L cells or they have a better functioning gut brain access.

So a smaller percentage of people will get away with just one capsule before a main meal and one capsule before dinner. So we want people to get used to it and just understand what their dosage. But 90% of people are 2 caps before lunch and dinner.

Like, I take 2 caps, but 5% of people make me get away with one.

I just want to go back to this point about biology and what most people don't realize is hunger is an evolutionary trait which was an asset to us during evolution, and it's controlled by our hind brain. If you reduce your calories by 25%, your hunger will double over four months. And that's stimulated by ghrelin, which is a hunger hormone.

Now, the reason for this is your body thinks it's going into a famine. And this is what forced us out of our caves and said, hey, go out and hunt. So it was an asset to us.

Now in the developed world, we're surrounded by food, so it's not so much of an asset. And this is why 99% of diets fail and women get women and men.

But let's talk about women get into this, this love hate relationship with food because it's all said it's about willpower. It is not about willpower. You know it is.

That's your forebrain, and your forebrain sits over your hindbrain and your forebrain saying, you don't need to eat this. You put stress hormones, lack of sleep or alcohol and that forebrain falls off and that hindbrain goes woo hoo, we're off.

So I always say to people, how many times have you had hot chips late at night after you've had something to drink? There's a lot of stigma around. You don't have willpower, you can't do that. It is biological.

It is your body saying your body fights you the whole time. So we are just a tool to help you with that.

Speaker B: 00:24:58

That is so true. I'm curious with, with the research you've done on, on this compound, are there any types of women that respond better?

So for example, people that have issues with metabolic flexibility, people under high stress, hormonal imbalances, you already mentioned, you know, during your cycle, certain parts of your cycle.

Speaker A: 00:25:20

Look, anytime get the dosage right, you could be the 5% that only take one, you know, so just get the dosage. And I mean I'm obviously going to say this because I'm the founder, but I take it every day.

hen it was presented to me in: 2017

That guiltiness, you know, I've eaten too much, I shouldn't have eaten that. I hate food. Yo yo dieting, all of those things. Oh my God. I am at peace.

I take it every day, but usually I only take it once a day, you know, unless I'm going to eat late at night. It's more my, my morning stages for me. And I can honestly say it's my, it's my godsend. I am at peace with food now. I don't yo yo diet.

I don't hate myself for eating, I just eat less. Killicob is my little helper. So I absolutely love it.

And just saying about our clinical trials, I will reiterate again, these are all done by the government. The government actually owns the technology and Amarisate, we just license it globally.

So all of the clinicals are done by the government, they're all published. So they are a pure science. And as I said, they may take a long time because pure science does take a long time and cost a lot.

But as you know, we're actually onto our fourth human clinical now which is 150 patients, men and women, six months and then a three month follow up and that'll be finished I think in July and we should have the first results in October because you know, they have to unblind it and they have statisticians and so on like that. But one of the key biomarkers we're measuring is white and body confirmation. So we know people lose weight.

You know, we get thousands of testimonials back from people. One of the key things they tell you to us is you take the noise out of my head. You know, we all know that food noise.

But this one will be, you know, as I said, double blind placebo. So yeah, it's costing $2 million. So we're keeping our fingers and our toes crossed.

Speaker B: 00:27:44

Well, most natural supplements definitely don't have such a vigorous research hardly ever because obviously it costs so much to do that. So it's kind of rare that a government who actually fund supplements develop.

Speaker A: 00:27:59

We're lucky. And you know, they've been incredible partners with us.

Speaker B: 00:28:05

I'm curious, these natural GLB1 activators, can they be like a good bridge or ramp off for people coming off of injectable peptides or even in combination? Do you have any experience with people using it that way?

Speaker A: 00:28:22

Look, you're absolutely. We just did a 50 patient trial in America with this. So 25 in combination and 25 coming off. And this will be published soon. The 25 coming off.

I say to doctors or practitioners, it's, it's not an if, it's a must. When you're on an external hormone, when you have an external hormone or synthetic hormone, you depress your natural hormones down to zero.

So you're on an injectable, it's great. But of course your natural hormones go, well, you know, I don't have to do anything, this is great and I'm going to have a rest for a while.

So when you come off the injectable, your natural that we talked about is down at zero. So you have to kick start this gut brain access. And remember, it's been having a great rest.

It's been in, you know, it's been on a tropical island for, you know, a few months. So you've got to kick start it again. And that's what Kalakub will do.

So we recommend in that week you're titrating off an injectable, start taking Kalakubin, start doing that onboarding.

So you're kickstarting that and superb result for that because we act as this enormous safety net and then people can continue to control their appetite and continue to eat more normally and get into this routine. And it's about that routine. So fantastic results with that. And there isn't a solution yet.

I just read a paper last night and it's like 90% gain back the weight they lost. It doesn't matter what injectable you're on. And we believe part of it is because your natural gut brain access is still on holiday.

And that's part of the reason. The other one you asked about in combination.

So practitioners, we've done a trial with 25 patients in clinic and practitioners were the one that told us about that, because they can lower the dosage.

So say it's a tirzepatide, they can lower it down to 0.25mg and they can lower it down to the lowest level, so reducing side effects and reducing the cost. And then use Kalicub at the same time. So you're getting an exogenous and an endogenous.

But where they're finding it really great is that breakthrough hunger at five to six days or even seven days before you have your next injection. It just make you maintain a low dase and take kallicurb at the same time. So yeah, they're using it for that.

Or you know, alternatively, if people can't take the side effects, they don't want to inject themselves. I call it injection fatigue or, or they can't afford it.

Speaker B: 00:31:22

Yeah.

And I would also argue, I think a lot of people gain the weight back when they come off of injectables because they haven't made the lifestyle changes at the same time.

If this is like a single lever approach and they just relying on the drug to do all the work, then obviously they're gonna fall back onto their old habits that aren't have not served them in the past.

So I think it's a combination of, while you are on the injectable, if you are on it, you gotta make the appropriate lifestyle changes, start eating better, more nutrient dense food, you gotta work out, you gotta manage your sleep. All those lifestyle habits need to be in place while you don't have that food noise. So you have more discipline to implement these things.

And then when you're ready to start titrating off your injectable, then you can start adding in these great supplements like this one to give you a softer landing so you don't have this crazy hunger coming back when you, when you're tighter off. Right.

And, and would you say the best way to potentially, when you get down into the lower doses of your injectable, you start taking this and then would you, when you completely get off your injectable, would you even increase the dose or you just stay on the 2 caps before meal dosing, just stay on.

Speaker A: 00:32:51

The 2 caps then you don't need any more than that. Just stay on the two caps. I would say it's great coming off, but you are 100% right. We are a tool in the toolkit. There has to be others.

It is nutrition, sleep, exercise, all of those. I always say if you go from 10 donuts to 8 donuts it's really going to make little difference.

So I will go back when you say great supplements we are and I know I'm sort of spouting my own importance here, but we are the only supplement in the world and remember we monitor this all of the time. That stimulates the release of GLP1 and CCK at 600% and just be aware you have to be above 400% to make any behavioral change whatsoever.

So you'll see other supplements that say we stimulate GLP1. Well yes they do. Anything stimulates GLP1. Eating some cheese will stimulate GLP1. Eating an apple will stimulate GLP1.

That is a natural, natural thing for your body to do. But you need to super stimulate it to make a behavioral change and that has to be above 400%.

Speaker B: 00:34:10

Yeah, that's a good clarification.

I only heard of one other supplement but maybe you're in the know of the GLP1 supplement market but I know Pendulum has a sort of a probiotic, probiotic type of combo supplement that have some claims on stimulating that. I don't know, I. It looks like a different mechanism of action of how that works.

And I wonder even taking something like that combination with your supplement, would that be a good stack or how would you first of all, if you can comment maybe on what else is on the market and secondly, what would be a good stack to take calcur with if you have some recommendations of to make it even more powerful?

Speaker A: 00:34:55

Absolutely. A couple of things. Pendulum or Archementia is a probiotic and Akkermansia goes down to the lower gut and its purpose is it populates the lower gut.

And if you eat a non soluble fiber, Akermansia is supposed to breaks down that non soluble fiber to something called bitrate which stimulates GLP1 release. So it's sort of a one step, two step. They've never actually measured the GLP1 probiotics are great for digestive health.

So I think certainly an Akermansia will help. It also will take 12 weeks. So we work in an hour. That takes 12 weeks to work. But certainly probiotics are good for intestinal health.

I would say, hey, yep, take a probiotic. I think one of the best. And it's not so much a supplement protein. You know, people forget about protein.

Protein is so important for particularly in women getting older. You know, we do have a decrease in our muscles called sarcopenia. So protein will help to keep that muscle mass alongside resistance training.

And also people from get protein is a good satiety as well. You know it fills the stomach and it is a good satiety mechanism. Like a whey protein woman particularly do not get enough protein.

And it's quite hard to get enough protein in during the day. You gotta have 100 to 120 grams depending on your size. People think, oh I like eggs each an egg is only 6 grams of protein.

So even two eggs are gonna give you 12, you're only 12 grand, you're only 10% of the way there. So how do you get in this protein during the day? And I often think a protein drink is a good way to do that.

I'm a big proponent of protein probiotics but if you want to manage your appetite quickly, that's kalakib and that's what you know it will work in an hour.

Speaker B: 00:37:03

I think any type of gut supporting supplement stack will be helpful to improve GI function, reduce leaky guts and obviously just the whole food diet.

I a hundred percent agree with the emphasis on protein because whether you're on the injectable or taking a supplement, but if you are cutting out calories, you're cutting out, let's just say 20, 30% of your calories, then you have to have a completely protein forward diet in order to get enough protein in. So and as you said as soon as you consume that it's also very satiating. So you already have a lesser appetite.

And then on top of that if you eat the protein first, that's gonna sort of stack it in your favor of, of having less of a hunger.

Speaker A: 00:37:50

And it's hard, you know, who takes a chicken breast to lunch? You know, it's quite hard to get that. So I am a proponent of particularly for women but you know, get a whey protein isolate or something like that.

Other things called amino acids or pure amino acids might be of help to because they don't put pressure on the kidney. So those are, those are what practitioners talk to me about. But I absolutely that's my biggest thing.

Speaker B: 00:38:18

Is that I would almost anybody, anybody who's on GLP1s I, I suggest they do some sort of an amino acid supplement during the day. Because that doesn't really have much calories. It's easier to get it down, but it's help you meet your amino acid requirements.

Have a protein shake too, and then maybe some creatine, lift some heavy weights, do all those things.

And also I always tell everyone you need to actually track your protein intake at least for a few days because unless you do, you don't realize how little you're eating. Like everybody tells me like, oh yeah, I ate enough protein. And then they track it and they realize they eat half of what they should eating.

Speaker A: 00:39:01

It's not, it is hard, you know, and particularly in the middle of the day, it's like, oh, I had a ham sandwich.

But if you look at the amount of ham or you look at the amount of chicken sandwich, you look at the amount of chicken, you know, it won't be very much. You better to have a big piece of chicken if you can forget, you know, and forget the bread on either side of it.

Speaker B: 00:39:23

And also just to try, try to prioritize protein as snacks, which is hard because most proteins are usually carbs.

But, but if you can find protein snacks, like the ones that I really like are like these paleo sticks that are mostly beef or like beef jerky, or eating a protein bar or the protein drinks, those are, those are really good option. Or even just having hard boiled eggs, things like that as, as your snacks. And believe me, that's very satiating.

If you have that you are not hungry afterwards versus if you have some sort of a carby snack, you'll, you'll be hungry a half, half an hour later. Right?

Speaker A: 00:40:03

We love it in the US because you know, we're always dipping into CVS or something like that and grabbing hard boiled eggs because you know, we don't, we can't get them. Well, I mean, obviously we have eggs in New Zealand, but no one sells them as hard boiled eggs. So we think America's great for that.

We're always nipping into one of the stores and getting a bag of ham. Oh God, we sound boring, don't we? But it does help us during the day.

Speaker B: 00:40:28

So for people that take the supplement, just a supplement and they want to lose a certain amount of weight, what kind of body composition change or weight loss can they expect over how much time? Like do you have any data on losing weight or body count change over let's just say six months or a year or any, any type of information like that?

Speaker A: 00:40:53

Obviously, anecdotally, you know, we have a lot. I will give you a comparison on A semaglutide, which is your injectable wegovy.

On a semiglutide, you eat on average 24% less a day, 24% less calories. You know, as we said on Kalicurb, we know we on average reduce the calorie intake by 18%. So there's a comparison to that.

We will have the confirmed data when this clinical trial comes out on body loss and body composition. The results we've had back is almost all fat loss and no muscle loss.

I'm just saying what we've had back anecdotally and we will have a clinical, our full clinical out by October and we measured both weight loss, body composition, blood glucose, liver function, all of those.

And what I'm really interested in, and you will like is at the end of this six month, we've measured the, the GLP one prior to going into it and along the way and at the end. And the scientists believe, the government scientists believe that we are up regulating these L cells which have the little bit of taste.

So we're upbringing, so we're actually making your gut brain access better. Often you can depress them, but they believe it's upregulating. So we're actually making a better gut brain access.

So I'm really interested in that and I kind of try to describe it. Like these little cells are like we're exercising them every day and you know, when you exercise something they become stronger.

So that's how I'm thinking about it.

Speaker B: 00:42:42

That's quite remarkable if that really can be proven because I think with the injectable you're kind of doing the opposite, you're almost taking them offline.

Whereas if this actually does the opposite, then it makes you healthier at the end or at least upregulates your GLP1 production and you are able to regulate your own appetite better once you stop using the supplements. Am I saying that right?

Speaker A: 00:43:09

Yes, you are. And remember, you can take kalakoub intermittently as well. It doesn't last.

You know, it's like I'm going out for a really yummy meal but I wouldn't take my kalakub now. You know, I don't know if I'm going out to say a dega station dinner or something.

I'm like, no, I want to eat this, but other times on holiday I pack it all the time so I don't eat too much, too much and to manage it better. And this is this upregulation, the other thing that we didn't talk about you do depress your own endogenous GLP1 down to zero. Absolutely.

That is clinically shown, or almost zero. The other thing you're depressing is other things like GLP2.

So in these L cells you're releasing GLP1, which is appetite suppressing, and GLP2, which is intestinal health. So you want to be super stimulating. So with this trial as well, we're measuring the GLP2 that we're stimulating.

So there's a whole lot of things that you do. As you know, whenever you take anything synthetic, we tend to use a sledgehammer versus a hammer. So, you know, and at very high levels.

Speaker B: 00:44:16

Just to wrap this up, what are the most common misconception you hear about natural weight loss supplements or appetite suppressants and what is actually true?

Speaker A: 00:44:26

This is why it's such a. It is a difficult area because there are so many, and I read so many, what I would call scammy products.

They've got no science behind them and they don't actually work. So before this came up, there were three natural products, as I said to you.

One is a filler, which is, you know, when you eat a lot of fibre and so you're going to feel full but you're going to feel very bloated. It's just fiber in your stomach. That was quite common. The other one is a caffeine baked stimulator. So, you know, it gives you the jitters.

So what it does is it speeds up your metabolism and then the other one is a laxative. So I think we talked about things in. You look for science based. Always look at the clinicals and make sure the clinicals are published.

If they're published, they will show you that they've been done on the right amount of people, they've been peer reviewed, they're high quality science. You know, I read these the whole time and if they're not published, I'm like, really? You know, because you're not getting a.

Statistically, I saw one the other day, I won't mention the brand name and I'm like, really? You know, you know, when I looked at the clinical, when I went in and looked at the clinical, there was no difference between placebo and control.

And I'm like, you're making these claims, but there's no difference. So I get cross myself because this is why people are skeptical and I can understand that. And I get grumpy about it as well.

So all I can say is really look for the science.

Speaker B: 00:46:05

Yeah.

And that's why I personally don't have a lot of supplement companies on my podcast because it's very hard to prove some claims that that supplements make unless they have proper research as, as you mentioned and most supplement companies just don't have the financial resources to, to do that. I think that's just, that's the truth. So a lot of the claims that.

Speaker A: 00:46:31

Are at such a low level, that ingredient may have had some results, but they'll add it at a level which is so low that it won't make a difference. We own the ingredient from source to shelf and we're supported by the government and with, with all of this work. So yeah, I do know this.

We've almost taken a pharma approach to a nutraceutical. But I'm also very proud of the results, particularly as I said, the woman clinical. We did.

Speaker B: 00:47:06

Yeah.

And because there's only so many nutraceuticals that are strong enough to fall into this category and obviously worth the spend on research and all the money that the New Zealand government spent on it to do these clinical trials. So what is the best way to get a hold of this supplement? How can people find it and learn more about it?

Speaker A: 00:47:30

We are on just a look at and you get all the research as well on ww.calico c a l o c u r b dot com and just go on there and you will get all the clinicals on there, all of the mode of action and how to order it.

Speaker B: 00:47:51

Yeah. And we'll have a link in our show notes for all our listeners so you can find it and order it. And I believe it has a discount associated with it.

Speaker A: 00:48:01

Yes, you'll have a discount code for.

Speaker C: 00:48:49

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